Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pan
![The small molecule drug CBL0137 increases the level of DNA damage and the efficacy of radiotherapy for glioblastoma - ScienceDirect The small molecule drug CBL0137 increases the level of DNA damage and the efficacy of radiotherapy for glioblastoma - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0304383520306248-gr7.jpg)
The small molecule drug CBL0137 increases the level of DNA damage and the efficacy of radiotherapy for glioblastoma - ScienceDirect
Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pan
![CBL0137 preferentially kills GSCs over NSTCs by targeting FACT. A, GSCs... | Download Scientific Diagram CBL0137 preferentially kills GSCs over NSTCs by targeting FACT. A, GSCs... | Download Scientific Diagram](https://www.researchgate.net/profile/Josephine-Kam-Tai-Dermawan-2/publication/295256227/figure/fig2/AS:363837397192705@1463757003296/CBL0137-preferentially-kills-GSCs-over-NSTCs-by-targeting-FACT-A-GSCs-CD133-th-red.png)
CBL0137 preferentially kills GSCs over NSTCs by targeting FACT. A, GSCs... | Download Scientific Diagram
![Effective inhibition of MYC-amplified group 3 medulloblastoma by FACT-targeted curaxin drug CBL0137 | Cell Death & Disease Effective inhibition of MYC-amplified group 3 medulloblastoma by FACT-targeted curaxin drug CBL0137 | Cell Death & Disease](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41419-020-03201-6/MediaObjects/41419_2020_3201_Fig5_HTML.png)
Effective inhibition of MYC-amplified group 3 medulloblastoma by FACT-targeted curaxin drug CBL0137 | Cell Death & Disease
Acute exposure to CBL0137 decreases CD133 cell-surface expression and... | Download Scientific Diagram
Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG
![em>TP53</em> loss‑of‑function mutations reduce sensitivity of acute leukaemia to the curaxin CBL0137 em>TP53</em> loss‑of‑function mutations reduce sensitivity of acute leukaemia to the curaxin CBL0137](https://www.spandidos-publications.com/article_images/or/47/5/or-47-05-08310-g00.jpg)
em>TP53</em> loss‑of‑function mutations reduce sensitivity of acute leukaemia to the curaxin CBL0137
![Effective inhibition of MYC-amplified group 3 medulloblastoma by FACT-targeted curaxin drug CBL0137 | Cell Death & Disease Effective inhibition of MYC-amplified group 3 medulloblastoma by FACT-targeted curaxin drug CBL0137 | Cell Death & Disease](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41419-020-03201-6/MediaObjects/41419_2020_3201_Fig3_HTML.png)
Effective inhibition of MYC-amplified group 3 medulloblastoma by FACT-targeted curaxin drug CBL0137 | Cell Death & Disease
Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pan
![Potent antileukemic activity of curaxin CBL0137 against MLL‐rearranged leukemia - Somers - 2020 - International Journal of Cancer - Wiley Online Library Potent antileukemic activity of curaxin CBL0137 against MLL‐rearranged leukemia - Somers - 2020 - International Journal of Cancer - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/45902234-d3d0-46a4-8290-135a18580d23/ijc32582-fig-0002-m.jpg)
Potent antileukemic activity of curaxin CBL0137 against MLL‐rearranged leukemia - Somers - 2020 - International Journal of Cancer - Wiley Online Library
![Australian Researchers Find New Way to Target Deadly Childhood Cancer With CBL0137 | The Cure Starts Now Australian Researchers Find New Way to Target Deadly Childhood Cancer With CBL0137 | The Cure Starts Now](https://thecurestartsnow.org/media/3872/ziegler.jpg)
Australian Researchers Find New Way to Target Deadly Childhood Cancer With CBL0137 | The Cure Starts Now
Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG
![CBL0137 inhibits EPC in vitro. a A 13-nucleosome 601207 × 13 array for... | Download Scientific Diagram CBL0137 inhibits EPC in vitro. a A 13-nucleosome 601207 × 13 array for... | Download Scientific Diagram](https://www.researchgate.net/profile/Omar-Kantidze/publication/332078189/figure/fig2/AS:958984345358355@1605651093597/CBL0137-inhibits-EPC-in-vitro-a-A-13-nucleosome-60120713-array-for-EPC-rate-analysis30.png)
CBL0137 inhibits EPC in vitro. a A 13-nucleosome 601207 × 13 array for... | Download Scientific Diagram
![IJMS | Free Full-Text | Exploring the Interaction of Curaxin CBL0137 with G-Quadruplex DNA Oligomers | HTML IJMS | Free Full-Text | Exploring the Interaction of Curaxin CBL0137 with G-Quadruplex DNA Oligomers | HTML](https://www.mdpi.com/ijms/ijms-22-06476/article_deploy/html/images/ijms-22-06476-g001.png)